Characterizing and Mitigating Bladder Radioactivity on 18F-Fluciclovine PET/CT

FDA Approves 18F-Fluciclovine and 68Ga-DOTATATE Products.

T hrough its Priority Review mechanism, the U.S. Food and Drug Administration (FDA) recently approved 2 radiopharmaceutical products for use as diagnostic PET agents. The first, approved on May 27, was Axumin (18F-fluciclovine) injection, indicated for use in PET imaging to identify suspected sites of prostate cancer recurrence in men with elevated levels of prostate-specific antigen (PSA) foll...

Assessment of Amino Acid/Drug Transporters for Renal Transport of [18F]Fluciclovine (anti-[18F]FACBC) in Vitro

[18F]Fluciclovine (trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid; anti-[18F]FACBC), a positron emission tomography tracer used for the diagnosis of recurrent prostate cancer, is transported via amino acid transporters (AATs) with high affinity (Km: 97-230 μM). However, the mechanism underlying urinary excretion is unknown. In this study, we investigated the involvement of AATs and drug ...

Characterizing and mitigating communication challenges in wireless and mobile networks

Characterizing and Mitigating Web Performance Bottlenecks in Broadband Access Networks

We present the first large-scale analysis of Web performance bottlenecks as measured from broadband access networks, using data collected from two extensive home router deployments. We design and implement tools and methods to identify the contribution of critical factors such as DNS lookups and TCP connection establishment to Web page load times and characterize how they contribute to page loa...

Characterizing and Mitigating the DDoS-as-a-Service Phenomenon

Distributed Denial of Service (DDoS) attacks are an increasing threat on the Internet. Until a few years ago, these types of attacks were only launched by people with advanced knowledge of computer networks. However, nowadays the ability to launch attacks have been offered as a service to everyone, even to those without any advanced knowledge. Booters are online tools that offer DDoS-as-a-Servi...